New article describing the only lytic phages known to infect the spirochete Leptospira

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With our colleagues of the Institut Pasteur Paris we sequenced and analysed the first genomes of the lytic phages LE3 and LE4 that can infect the saprophyte Leptospira biflexa using the lipopolysaccharide O-antigen as receptor. Bioinformatics analysis showed that the 48-kb LE3 and LE4 genomes are similar and contain 62% genes whose function cannot be predicted.

Read the full paper online here

Figure 1

Figure 1

Transmission electron micrographs of leptophages. Morphology of leptophages (A) LE1, (B) LE3, and (C) LE4. Scale bar represents 100 nm. (D) Magnification of L. biflexa strain Patoc 1 (cell length of 10 µm) six hours after infection with phage LE4 (MOI=10). Arrowheads indicate representative phages. Scale bar represents 200 nm.